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President's Message

2012 Conference Toluca, Mexico


In the News

Stephen D. Miller, Ph.D. PDF Print E-mail

ImageStephen D. Miller, Ph.D.
Director, Interdepartmental Immunobiology Center
Dept. of Microbiology Immunology
Northwestern University Medical School
6-713 Tarry Building
303 E. Chicago Avenue
Chicago, IL 60611
Tel (312) 503 7674
Fax (312) 503 1154
e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Dr. Stephen Miller received his Ph.D. in Immunology in 1975 from the Pennsylvania State University and did postdoctoral work in Cellular Immunology from 1975-78 at the University of Colorado Medical School in Denver with Dr. Henry N. Claman. He assumed a junior faculty position at the University of Colorado from 1978-81 and was then appointed Assistant Professor of Microbiology-Immunology at Northwestern University Medical School in June, 1981. Since 1992 he has been a Professor of Microbiology-Immunology and Director of the Northwestern University Interdepartmental Immunobiology Center. Since 1995, he has directed the NIH-funded Immunology and Molecular Pathogenesis Training Program. From 2000-2007, Dr. Miller was the Congressman John E. Porter Professor of Biomedical Sciences and in December 2007 was invested as the Judy Gugenheim Research Professor of Microbiology-Immunology. He currently serves on the editorial boards of Cellular Immunology, Viral Immunology, Virology, the European Journal of Immunology, and the Journal of Autoimmunity. He also serves as a member of the Steering Committee for the NIH Immune Tolerance Network, as a member of the Juvenile Diabetes Research Foundation Immunology Study Section. Dr. Miller was elected as a Fellow of the American Association for the Advancement of Science in 2004 and as a Fellow of the American Academy of Microbiology in 2007.

Dr. Miller’s laboratory investigates the cellular and molecular mechanisms of multiple aspects of the immunopathogenesis and immunoregulation of CD4+ T cell-mediated autoimmune diseases. His research employs two mouse models of multiple sclerosis (MS) - Theiler's virus-induced demyelinating disease (a virus-induced model of MS) and Relapsing Experimental Autoimmune Encephalomyelitis (R-EAE) (an autoimmune model of MS), as well as the NOD mouse model of type 1 diabetes. The laboratory examines the mechanisms by which epitope spreading (the process whereby self tissue destruction results in activation and recruitment of autoreactive T/B cells specific for endogenous self antigens) and molecular mimicry (the process whereby immune responses to viral epitopes cross-react with self tissue determinants) lead to induction and/or progression of autoimmunity. The laboratory also studies the cellular and molecular mechanisms whereby peptide-specific tolerance, antibodies directed against lymphocyte costimulatory/homing pathways (e.g., B7/CD28, CD40/CD40L, and VCAM-1/VLA-4), antigen-specific CD4+CD25+Foxp3+ regulatory T cells can be used to control established autoimmune disease and tissue transplantation rejection. His research is currently funded by five separate grants from the U.S. National Institutes of Health, and by grants from the U.S. National Multiple Sclerosis Society, the Myelin Repair Foundation, and the Juvenile Diabetes Research Foundation. He has published over 275 scientific articles.